All photos copyright WG Pyle.


Heart failure, once considered a disease of the western world, is an increasingly common threat to global health. Our laboratory is interested in uncovering the mechanisms of heart failure, and developing novel and more effective therapies to treat this condition. Our research programme spans all levels of research, from molecular changes that cause hearts to fail, to the translation of results into therapies for patients.

Principal Investigator

Dr. Pyle received his BSc in Human Kinetics from the University of Guelph. He completed his doctoral work in Physiology and Biophysics at the University of Tennessee Health Sciences Center under the supervision of Dr. Polly Hofmann, followed by an American Heart Association Post-Doctoral Fellowship at the University of Illinois (Chicago) with Drs. John Solaro, Pieter de Tombe, and Peter Buttrick in the Departments of Physiology and Biophysics and the Division of Cardiology.


Dr. Pyle's research has garnered awards from the International Society for Heart Research, American Heart Association, Canadian Institutes of Health Research, Canadian Cardiovascular Society, and the Heart and Stroke Foundations of Canada and Ontario. He is a Senior Career Investigator for Improving the Heart & Brain Health for Women in Canada (Heart & Stroke Foundation of Canada & Health Canada). Dr. Pyle is the recipient of a Premier's Research Excellence Award from the Government of Ontario, and his research has been supported by the Heart and Stroke Foundation, Canadian Institutes of Health Research, National Science and Engineering Research Council, U.S. National Institutes of Health, and the OVC Pet Trust. Dr. Pyle serves on the editorial boards of the Journal of Molecular and Cellular Cardiology, American Journal of Physiology (Heart and Circulatory Physiology), and Biomolecules, and is an active reviewer for the Heart and Stroke Foundation of Canada and the Canadian Institutes of Health Research.